PDGF receptor kinase inhibitors for the treatment of restenosis.
نویسنده
چکیده
The clogging of arteries by neointima is a hallmark of atherosclerosis and of restenosis following balloon angioplasty. The realization in the 1980s that PDGF and its receptor play a key role in the onset of neointimal formation led us to develop PDGFR kinase inhibitors as antirestenosis agents. In this review, we describe the development of these inhibitors and their implementation as antirestenosis agents by localized delivery to the site of injury.
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ورودعنوان ژورنال:
- Cardiovascular research
دوره 65 3 شماره
صفحات -
تاریخ انتشار 2005